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Proceedings Paper

High-speed wide-field multi-parametric photoacoustic microscopy (Conference Presentation)

Paper Abstract

We report a new multi-parametric photoacoustic microscopy (PAM) system, which enables high-resolution imaging of blood perfusion, oxygenation and flow at 0.2-Hz frame rate over an area of 4.5×4.5 mm2. Extending the laser scanning range by using a cylindrically focused transducer (focus: 50 µm by 4.5 mm), it increases the speed of our previous hybrid-scan system with a weakly focused transducer (focal diameter: 250 µm) by 18-fold without compromising the sensitivity. We have demonstrated the feasibility of this technique in the transmission mode in vivo. Further development of a reflection-mode system will enable real-time cortex-wide imaging of cerebral hemodynamics and metabolism.

Paper Details

Date Published: 6 March 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401Y (6 March 2020); doi: 10.1117/12.2545036
Show Author Affiliations
Fenghe Zhong, Univ. of Virginia (United States)
Ruimin Chen, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Song Hu, Univ. of Virginia (United States)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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