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Proceedings Paper

Hybrid organosilicon/polyol phantoms for applications in biophotonics and beyond
Author(s): Lucia Cavigli; Sonia Centi; Claudia Borri; Giada Magni; Andrea Barucci; Marina Mazzoni; Roberto Carpi; Roberto Incalcaterra; Giacomo Belli; Roberto Pini; Fulvio Ratto
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Paper Abstract

Recent advances of medical technologies are demanding a new generation of phantoms that may encode the biophysical features needed for their assessment. Here, we propose hybrid materials based on emulsions of polydimethylsiloxane with glycerol or aqueous polyvinyl alcohol as a versatile platform for phantoms for applications such as optical, acoustic, magnetic resonance or X-ray imaging. These materials display intrinsic optical scattering, retain the acoustic features of polydimethylsiloxane, enable the inclusion of a broad taxonomy of hydrophobic and hydrophilic dyes of interest for photoacoustic imaging, may be suitable to simulate the cellularity of organs due to their peculiar microstructure, and, thanks to the possibility to include aqueous solutions of metabolites, may be of interest for magnetic resonance imaging and computed tomography

Paper Details

Date Published: 17 February 2020
PDF: 5 pages
Proc. SPIE 11231, Design and Quality for Biomedical Technologies XIII, 112310S (17 February 2020); doi: 10.1117/12.2545002
Show Author Affiliations
Lucia Cavigli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Sonia Centi, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Claudia Borri, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Giada Magni, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Andrea Barucci, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Marina Mazzoni, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Roberto Carpi, Azienda USL Toscana Ctr. (Italy)
Roberto Incalcaterra, Azienda USL Toscana Ctr. (Italy)
Giacomo Belli, Azienda Ospedaliera Careggi (Italy)
Roberto Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Fulvio Ratto, Istituto di Fisica Applicata "Nello Carrara" (Italy)


Published in SPIE Proceedings Vol. 11231:
Design and Quality for Biomedical Technologies XIII
Jeeseong Hwang; Gracie Vargas, Editor(s)

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