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Proceedings Paper

Photoacoustic and fluorescent microscopy through a multimode fiber by use of optical wavefront shaping (Conference Presentation)

Paper Abstract

Many applications of microendoscopy, including brain imaging, requires minimally invasive devices to minimize damage during insertion in the tissue. Here we present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. By learning the transmission matrix during a prior calibration step, a focused spot can be produced and raster-scanned over a sample at the distal tip of the fiber by use of a spatial light modulator. We demonstrate that our setup provides both photoacoustic and fluorescence microscopic images of test samples in vitro (fluorescent beads and red blood cells) through the same fiber.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124027 (6 March 2020); doi: 10.1117/12.2544967
Show Author Affiliations
Sylvain Mezil, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)
Irène Wang, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)
Philippe Moreau, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)
Théodore Remark, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)
Antonio M. Caravaca-Aguirre, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)
Emmanuel Bossy, Lab. Interdisciplinaire de Physique, CNRS (France)
Univ. Grenoble Alpes (France)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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