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Proceedings Paper

Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve (Conference Presentation)
Author(s): Mohsen Erfanzadeh; Ahhyun S. Nam; Marek Hansdorfer; Kasey Kwong; Mark A. Randolph; Robert W. Redmond; Benjamin J. Vakoc

Paper Abstract

We demonstrate wide-field intraoperative in vivo PS-OCT and OCT-A imaging of non-human primate (NHP) peripheral nerves using a portable OCT prototype. Imaging was performed on healthy and surgically repaired (12 months after graft surgery) radial nerves in upper extremity of rhesus macaques (n=17) over surgically exposed nerve segments of up to 8 cm in length. We describe the capabilities and challenges of PS-OCT and OCT-A in assessing NHP peripheral nerves. Further, guided by imaging of NHP peripheral nerves, we discuss the required advancements in core polarimetry techniques to enhance the prospects of clinical utility of PS-OCT in peripheral nerve imaging.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510M (10 March 2020); doi: 10.1117/12.2544939
Show Author Affiliations
Mohsen Erfanzadeh, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Ahhyun S. Nam, Massachusetts General Hospital (United States)
Marek Hansdorfer, Massachusetts General Hospital (United States)
Kasey Kwong, Massachusetts General Hospital (United States)
Mark A. Randolph, Massachusetts General Hospital (United States)
Robert W. Redmond, Massachusetts General Hospital (United States)
Benjamin J. Vakoc, Massachusetts General Hospital (United States)
Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 11251:
Label-free Biomedical Imaging and Sensing (LBIS) 2020
Natan T. Shaked; Oliver Hayden, Editor(s)

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