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Proceedings Paper

Comparison of foveal avascular zone in diabetic retinopathy, high myopia, and normal fundus images
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Paper Abstract

To quantitatively describe and evaluate a new image processing technique for estimating the Foveal Avascular Zone (FAZ) in subjects with Diabetic Retinopathy and myopes. From a total of 328 images obtained from Diabetic Retinopathy (113), myopes (120) and normal (93), the FAZ dimensions were quantified using a new image processing algorithm. These parameters were also determined manually and by the OCT manufacturer’s inbuilt algorithm. In the new technique, the images were first pre-processed by using a DOG filter iteratively before being complemented followed by a Prewitt edge detection and repeated image dilation at angles of 00, 450 and 900. Image closure was then applied followed by noise and small object removal which resulted in the segmented boundary. For deeper insight into shape change, in addition to the diameter of the FAZ other parameters such as the area, diameter, major axis, minor axis, orientation, perimeter vessel avascular density (VAD), Vessel diameter Index (VDI), etc. were obtained. The circularity index was calculated using the FAZ area and perimeter parameters. The mean FAZ diameter (mm) by the new automated technique, manual-segmentation (ground truth), and inbuilt instrument algorithm were 0.67 ± 0.87, 0.67 ± 0.72 and 0.61 ± 0.14. The mean of FAZ area (mm2) was 0.36 ± 0.10, 0.33 ± 0.09 and 0.43 ± 0.14 in normal, myopia and diabetic subjects respectively. The new technique shows considerable improvement in accuracy (mean ± SD) when compared to the inbuilt system segmentation and the ground truth (manual marking by an expert clinician). The study results show that the FAZ area in Diabetic Retinopathy is significantly different (p=0.003) when compared to myopic eyes (p=0.016) and normals.

Paper Details

Date Published: 19 February 2020
PDF: 12 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181O (19 February 2020); doi: 10.1117/12.2544817
Show Author Affiliations
Jothi J. Balaji, Medical Research Foundation, Sankara Nethralaya (India)
Arpit Agarwal, Indian Institute of Technology Kanpur (India)
Rajiv Raman, Shri Bhagwan Mahavir Vitreoretinal Services (India)
Vasudevan Lakshminarayanan, Univ. of Waterloo (Canada)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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