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Proceedings Paper

Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)

Paper Abstract

We demonstrate imaging of amyloid-beta plaques in ex-vivo Alzheimer’s disease brain tissue using a 1060 nm swept source optical coherence tomography setup. This instrument enabled a global investigation of the brain tissue with a large field of view of 8 mm x 8 mm as well as sequential high resolution imaging. Amyloid-beta (A-β) plaques were identified as highly scattering features. Results were in good agreement with immunohistochemically stained images gained by histology.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260T (9 March 2020); doi: 10.1117/12.2544765
Show Author Affiliations
Matthias Salas, Medizinische Univ. Wien (Austria)
Johanna Gesperger, Medizinische Univ. Wien (Austria)
Antonia Lichtenegger, Medizinische Univ. Wien (Austria)
Michael Niederleithner, Medizinische Univ. Wien (Austria)
Laurin Ginner, Medizinische Univ. Wien (Austria)
Adelheid Woehrer, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Tilman Schmoll, Medizinische Univ. Wien (Austria)
Wolfgang Drexler, Medizinische Univ. Wien (Austria)
Rainer A. Leitgeb, Medizinische Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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