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Proceedings Paper

Analyzing birefringence in the retinal nerve fiber layer of diabetic patients using polarization sensitive OCT
Author(s): Sylvia Desissaire; Andreas Pollreisz; Felix Datlinger; Dorottya Hajdu; Stefan Steiner; Clemens Vass; Florian Schwarzhans; Michael Pircher; Ursula Schmidt-Erfurth; Christoph K. Hitzenberger
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Paper Abstract

Diabetes is a chronic metabolic disease characterized by elevated levels of blood glucose. Over time, it can lead to serious damages in the body. In the eyes, diabetic retinopathy (DR), the most common microvascular complication of diabetes, is a major cause of blindness. OCT can be used to provide high resolution images of the damages in the retina and follow their evolution over time. It is however still unclear which of the vascular or neurologic changes happen first in the development of the disease. In this work, we investigate the birefringence of the retinal nerve fiber layer (RNFL) of diabetic patients (with different stage of DR or no DR) and compare these results to healthy subject’s data. We use a PS-OCT system with an integrated retinal tracker for imaging (center wavelength of 860 nm, A-scan rate of 70 kHz). For each eye imaged, a raster scan centered on the optic nerve head (ONH) and a circular scan around the ONH (radius: 1.5mm) are taken. Considering only areas with a RNFL thickness >100 μm, birefringence values are calculated from an averaged circular tomogram for each eye. We observe a statistically significant reduced birefringence of the RNFL in the diabetic patients compared to the healthy volunteers.

Paper Details

Date Published: 19 February 2020
PDF: 5 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181G (19 February 2020); doi: 10.1117/12.2544701
Show Author Affiliations
Sylvia Desissaire, Medizinische Univ. Wien (Austria)
Andreas Pollreisz, Medizinische Univ. Wien (Austria)
Felix Datlinger, Medizinische Univ. Wien (Austria)
Dorottya Hajdu, Medizinische Univ. Wien (Austria)
Stefan Steiner, Medizinische Univ. Wien (Austria)
Clemens Vass, Medizinische Univ. Wien (Austria)
Florian Schwarzhans, Medizinische Univ. Wien (Austria)
Michael Pircher, Medizinische Univ. Wien (Austria)
Ursula Schmidt-Erfurth, Medizinische Univ. Wien (Austria)
Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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