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Proceedings Paper

Discrimination of brain tumor regional samples using combined visible light optical coherence microscopy and fluorescence imaging (Conference Presentation)

Paper Abstract

Maximal safe resection is of utmost importance when operating on intracranial tumors. However, the discrimination between physiological and malignant tissue is challenging. A solution is 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PPIX) fluorescence of malignant cells, which has evolved as powerful intraoperative tool for tumor identification. We investigated 43 samples obtained during 5-ALA guided surgery using a combined optical coherence microscopy (OCM) and fluorescence imaging system and compared results to cell density maps utilizing digital pathology. Based on fluorescence intensity, attenuation coefficients, and cell density, tumor core was differentiated from tumor-associated brain parenchyma with high sensitivity and specificity.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112261G (9 March 2020); doi: 10.1117/12.2544652
Show Author Affiliations
Johanna Gesperger, Medizinische Univ. Wien (Austria)
Antonia Lichtenegger, Medizinische Univ. Wien (Austria)
Thomas Roetzer, Medizinische Univ. Wien (Austria)
Pablo Eugui Arrizabalaga, Medizinische Univ. Wien (Austria)
Barbara Kiesel, Medizinische Univ. Wien (Austria)
Danielle Jade Harper, Medizinische Univ. Wien (Austria)
Conrad Wiliam Merkle, Medizinische Univ. Wien (Austria)
Marco Augustin, Medizinische Univ. Wien (Austria)
Georg Widhalm, Medizinische Univ. Wien (Austria)
Adelheid Woehrer, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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