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Proceedings Paper

Multimodal optical imaging for in vivo discrimination of equivocal melanocytic skin lesions
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Paper Abstract

Early diagnosis of melanoma is an ongoing challenge in dermatology and oncology. There is a special subgroup of melanocytic lesions that can be clinically and dermoscopically indistinguishable from early melanoma. The aim of the study was to improve the in vivo diagnostic possibilities for the differentiation of dermoscopic equivocal melanocytic lesions based on combination of multiphoton tomography (MPT) and optical coherence angiography (OCA). A multiphoton optical score (MPOS) for quantitative assessment of the melanoma features revealed by MPM was developed. OCA images were processed to calculate the vessel densities and the total lengths thin and thick vessels. Histopathological analysis separated the equivocal lesions into benign, melanoma in situ, and invasive melanoma. The MPOS value of benign lesions was significant lower than for the malignant ones. Quantitative analysis of OCA images revealed that the invasive melanoma type has the highest vessel density. The combined use of multiphoton tomography with MPOS calculation and quantification of optical coherence angiography data demonstrated a potential to discriminate all dermoscopic equivocal melanocytic lesions in vivo.

Paper Details

Date Published: 19 February 2020
PDF: 5 pages
Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 1121108 (19 February 2020); doi: 10.1117/12.2544597
Show Author Affiliations
Vadim Elagin, Privolzhsky Research Medical Univ. (Russian Federation)
Ekaterina Gubarkova, Privolzhsky Research Medical Univ. (Russian Federation)
Oksana Garanina, Privolzhsky Research Medical Univ. (Russian Federation)
Natalia Orlinskaya, Privolzhsky Research Medical Univ. (Russian Federation)
Diana Davydova, Privolzhsky Research Medical Univ. (Russian Federation)
Irina Klemenova, Privolzhsky Research Medical Univ. (Russian Federation)
Irena Shlivko, Privolzhsky Research Medical Univ. (Russian Federation)
Elena Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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