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Proceedings Paper

A luminescent oxygen-sensing hydrogel for mapping tissue oxygenation (Conference Presentation)

Paper Abstract

There is an unmet need for simple-to-use oximetry devices that can map tissue oxygenation over large areas while being easily integrated into clinical standard-of-care workflows. We present a phosphorescence-based approach which features red-emitting porphyrin molecule constructs, embedded within a paint-on hydrogel bandage for tissue oxygen concentration imaging. The bandage emission is visible by eye which enables oxygen imaging even in the presence of skin autofluorescence. Preclinical testing to validate correlations between bandage oxygenation maps and perfusion is ongoing, and by allowing gelation to occur on the skin the bandage can conform to odd topologies, such as ears.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560F (10 March 2020); doi: 10.1117/12.2544561
Show Author Affiliations
Haley L. Marks, Massachusetts General Hospital (United States)
Juan Pedro Cascales Sandoval, Massachusetts General Hospital (United States)
Joshua Glahn, Massachusetts General Hospital (United States)
Katherine Cook, Boston Univ. (United States)
Emmanuel Roussakis, Massachusetts General Hospital (United States)
Mark W. Grinstaff, Boston Univ. (United States)
Dieter Manstein, Massachusetts General Hospital (United States)
Conor L. Evans, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 11256:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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