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Proceedings Paper

Quantification of blood-brain barrier permeability with multiphoton fluorescence imaging (Conference Presentation)
Author(s): Lingyan Shi

Paper Abstract

Development of an optimal systemic drug delivery strategy to the brain will require non- invasive or minimally invasive methods to quantify the permeability of the cerebral microvessel wall or blood-brain barrier (BBB) to various therapeutic agents and to mea- sure their transport in the brain tissue.We developed a new drug delivery technique combine with multiphoton fluorescence imaging to quantify the BBB permeability. We then further applied ultrasound sonication combined with microbubble injection to open the BBB for drug delivery. The transient increase of BBB permeability was imaged and quantified by using multiphoton fluorescence microscopy.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112440T (9 March 2020); doi: 10.1117/12.2544525
Show Author Affiliations
Lingyan Shi, Univ. of California, San Diego (United States)


Published in SPIE Proceedings Vol. 11244:
Multiphoton Microscopy in the Biomedical Sciences XX
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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