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Proceedings Paper

Virtual screened peptides with high affinity to integrin α 5 β 1 for precise tumor identification and treatment
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Paper Abstract

Integrin α5β1 is a widely-recognized target for molecular probes in various pathological conditions, especially cancer. The development of computer screening approaches to identify novel high affinity ligands to tumor markers has paved the way for a new generation of tumor identification technology. In this study, we have developed an efficient pharmacophore-based computational strategy to screen two novel peptides, RYr and H5, with high affinity to integrin α5β1. Noninvasive optical imaging data showed that these two peptides could be specifically uptaken by α5β1 overexpressed-tumor cells in vitro and in vivo. And these peptides-based probes could retain in tumor tissue for precise tumor identification. Results indicated that the newly identified peptides with high affinity to integrin α5β1 can be used for precise tumor identification and treatment. And this work exploited more functionalities of pharmacophore-based computational strategy for screening targeting-peptides.

Paper Details

Date Published: 3 March 2020
PDF: 6 pages
Proc. SPIE 11241, Biophotonics and Immune Responses XV, 112410U (3 March 2020); doi: 10.1117/12.2544502
Show Author Affiliations
Zhihao Han, China Pharmaceutical Univ. (China)
Shuaishuai Gong, China Pharmaceutical Univ. (China)
Zhiyu Qian, Nanjing Univ. of Aeronautics and Astronautics (China)
Yueqing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 11241:
Biophotonics and Immune Responses XV
Wei R. Chen, Editor(s)

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