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Proceedings Paper

Quantitative multi-contrast in vivo rodent imaging with optical coherence tomography and angiography (Conference Presentation)
Author(s): Destiny Hsu; Ji Hoon Kwon; Ringo Ng; Jun Song; Myeong Jin Ju; Marinko V. Sarunic

Paper Abstract

Contrast for imaging the retinal microvasculature and the retinal pigment epithelium (RPE) is essential for pre-clinical studies of vision-robbing diseases. By integrating polarization diversity detection (PDD) with OCT angiography (OCTA), we have developed a novel quantitative multi-contrast OCT for imaging pigment in the RPE as well as flow in the retinal capillaries. An adaptive filter was developed for degree of polarization uniformity (DOPU) processing to provide improved measurements of melanin region thickness in tilted retina. The retinas of three mouse strains were imaged in vivo, with results demonstrating potential for simultaneous mapping of vasculature and melanin distribution in the RPE.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122827 (9 March 2020); doi: 10.1117/12.2544469
Show Author Affiliations
Destiny Hsu, Simon Fraser Univ. (Canada)
Ji Hoon Kwon, Simon Fraser Univ. (Canada)
Ringo Ng, Simon Fraser Univ. (Canada)
Jun Song, Simon Fraser Univ. (Canada)
Myeong Jin Ju, Dankook Univ. (Korea, Republic of)
Simon Fraser Univ. (Canada)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)

Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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