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Proceedings Paper

Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system
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Paper Abstract

Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (~ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ~ 150 μm and axial resolution of ~ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.

Paper Details

Date Published: 17 February 2020
PDF: 4 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400A (17 February 2020); doi: 10.1117/12.2544424
Show Author Affiliations
Guang Yang, Washington Univ. in St. Louis (United States)
Eghbal Amidi, Washington Univ. in St. Louis (United States)
William Chapman Jr., Washington Univ. in St. Louis (United States)
Hongbo Luo, Washington Univ. in St. Louis (United States)
Kexin Huang, Washington Univ. in St. Louis (United States)
Sreyankar Nandy, Washington Univ. in St. Louis (United States)
Atahar Mostafa, Washington Univ. in St. Louis (United States)
K. M. Shihab Uddin, Washington Univ. in St. Louis (United States)
Shuang Zhou, Washington Univ. in St. Louis (United States)
Heba Abdelal, Washington Univ. in St. Louis (United States)
Zahra Alipour, Washington Univ. in St. Louis (United States)
Deyali Chatterjee, Washington Univ. in St. Louis (United States)
Matthew Mutch, Washington Univ. in St. Louis (United States)
Quing Zhu, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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