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Proceedings Paper

Wavefront sensorless multimodal handheld adaptive optics scanning laser ophthalmoscope for in vivo imaging of human retinal cones
Author(s): Kristen Hagan; Theodore B. DuBose; David Cunefare; Corey Simmerer; Gar Waterman; Jongwan Park; Anthony N. Kuo; Ryan P. McNabb; Joseph A. Izatt; Sina Farsiu
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Paper Abstract

Adaptive optics scanning laser ophthalmoscopy (AOSLO) has advanced the study of retinal structure and function by enabling in vivo imaging of individual photoreceptors. Most implementations of AOSLOs are large, complex tabletop systems, thereby preventing high quality photoreceptor imaging of patients who are unable to sit upright and/or fixate for an imaging session. We have previously addressed this limitation in the clinical translation of AOSLO by developing the first confocal handheld AOSLO (HAOSLO) capable of cone photoreceptor visualization in adults and infants. However, confocal AOSLO images suffer from imaging artifacts and the inability to detect remnant cone structure, leading to ambiguous or potentially misleading results. Recently, it has been shown that non-confocal split-detection (SD) AOSLO images, created by the collection of multiply backscattered light, enables more reliable studies of retinal photoreceptors by providing images of the cone inner segment. In this paper, we detail the extension of our HAOSLO probe to enable multi-channel light collection resulting in the first ever multimodal handheld AOSLO (M-HAOSLO). Imaging sessions were conducted on two dilated, healthy human adult volunteers, and M-HAOSLO images taken in handheld operation mode reveal the cone photoreceptor mosaic. Aside from being the first miniaturized and portable implementation of a SD AOSLO system, M-HAOSLO relies on sensorless optimization of the wavefront to correct aberrations. Thus, we also show the first ever SD images collected after correction of the eye’s estimated wavefront.

Paper Details

Date Published: 19 February 2020
PDF: 6 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180X (19 February 2020); doi: 10.1117/12.2544407
Show Author Affiliations
Kristen Hagan, Duke Univ. (United States)
Theodore B. DuBose, Duke Univ. (United States)
David Cunefare, Duke Univ. (United States)
Corey Simmerer, Duke Univ. (United States)
Gar Waterman, Duke Univ. (United States)
Jongwan Park, Duke Univ. (United States)
Anthony N. Kuo, Duke Univ. (United States)
Ryan P. McNabb, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)
Sina Farsiu, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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