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Proceedings Paper

Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Paper Abstract

In oral cavity cancer only 15% of operations succeed in removing the whole tumor with the required margin of more than 5 mm of surrounding healthy tissue. This negatively affects prognosis. Clearly the hands and eyes of the surgeon do not suffice. We use a fiber optic needle probe for high-wavenumber Raman spectroscopic analysis of the freshly resected tissue to determine if the distance between the resection surface and the tumor is sufficient. A system is under development to inspect the resected tissue in under 15 minutes, while the patient is still in the OR.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123607 (9 March 2020); doi: 10.1117/12.2544394
Show Author Affiliations
Gerwin J. Puppels, RiverD International B.V. (Netherlands)
Elisa M. L. Barroso, Erasmus MC (Netherlands)
Yassine Aaboubout, Erasmus MC (Netherlands)
Maria Rosa Nunes Soares, Erasmus MC (Netherlands)
Viacheslav G. Artyushenko, art photonics GmbH (Germany)
Alexey Bocharnikov, art photonics GmbH (Germany)
Iskander Usenov, art photonics GmbH (Germany)
Tom C. Bakker-Schut, Erasmus MC (Netherlands)
Robert J. Baatenburg de Jong, Erasmus MC (Netherlands)
Eppo Wolvius, Erasmus MC (Netherlands)
Ivo ten Hove, Erasmus MC (Netherlands)
Hetty Mast M.D., Erasmus MC (Netherlands)
Jose A. U. Hardillo, Erasmus MC (Netherlands)
Aniel Sewnaik, Erasmus MC (Netherlands)
Cees Meeuwis M.D., Erasmus MC (Netherlands)
Florence van Lanschot, Erasmus MC (Netherlands)
Dominiek Monserez, Erasmus MC (Netherlands)
Stijn Keereweer, Erasmus MC (Netherlands)
Martin van der Wolf, RiverD International B.V. (Netherlands)
Elena Sokolova, RiverD International B.V. (Netherlands)
Senada Koljenovic, Erasmus MC (Netherlands)

Published in SPIE Proceedings Vol. 11236:
Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry
Wolfgang Petrich; Zhiwei Huang, Editor(s)

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