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Proceedings Paper

Plasmonic nanoparticles in agarose gel and filter paper-integrated microfluidic devices for SERS detection of molecules
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Paper Abstract

We will present surface enhanced Raman spectroscopy (SERS) detection of molecules using plasmonic nanoparticles that are embedded in agarose gel and in filter paper-integrated microfluidic channels, respectively. It has been known that, when SERS detection is performed in complex fluids such as cell culture media, a method to reduce interferences from a variety of molecules in the fluids on the detection results is very important. If continuous monitoring of molecules in cell culture media is needed, there should be a method to prevent large molecules such as proteins from reaching SERS substrates when sample solutions flow over the substrates. Since both agarose gel and filter paper can be used to separate molecules by size, in this study we have integrated them with plasmonic nanoparticles for SERS detection in complex fluids. We will report how to use filter paper-integrated microfluidic channels to detect melamine and sodium thiocyanate (NaSCN) in milk using SERS. In addition, we will demonstrate how to use plasmonic agarose gels to detect illegal drug in urine.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 1125702 (21 February 2020); doi: 10.1117/12.2544360
Show Author Affiliations
Li-An Wu, National Yang-Ming Univ. (Taiwan)
Yun-Chu Chen, National Yang-Ming Univ. (Taiwan)
Wen-Chi Pai, National Yang-Ming Univ. (Taiwan)
Yun-Hsian Hsu, National Yang-Ming Univ. (Taiwan)
Yih-Fan Chen, National Yang-Ming Univ. (Taiwan)

Published in SPIE Proceedings Vol. 11257:
Plasmonics in Biology and Medicine XVII
Tuan Vo-Dinh; Ho-Pui A. Ho; Krishanu Ray, Editor(s)

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