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Proceedings Paper

A pilot study: infrared laser stimulation of the rat vagus nerves
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Paper Abstract

The vagus nerve originating from the brainstem in the central nervous system is a long cranial nerve that reaches the neck, thorax, abdomen, and colon. It plays a role in autonomic nervous, cardiovascular, gastrointestinal, and immune systems. Electrical stimulation of the vagus nerve has become a standard method for the treatment of neuropathic pain and epileptic conditions over the years. Infrared laser nerve stimulation (ILNS) is an evolving technique that uses infrared laser energy to stimulate cells with electrochemical capacity without the need for external agents or physical contact. This pilot study explores infrared laser stimulation of the rat vagus nerve, in-vivo. An infrared pigtailed singlemode diode laser operating at 1505 nm in continuous-wave (CW) mode was used in this study for noncontact CW-ILNS. Successful CW-ILNS of the rat vagus nerve was observed after the CN reached a threshold temperature of ~44°C with response times as short as 10 s. With more improvement in instrumentation, better optimization of stimulation parameters, and a higher sample size, CW-ILNS may show some potential in vagus nerve stimulation for preclinical.

Paper Details

Date Published: 20 February 2020
PDF: 6 pages
Proc. SPIE 11238, Optical Interactions with Tissue and Cells XXXI, 1123816 (20 February 2020); doi: 10.1117/12.2544355
Show Author Affiliations
Ozan Yetis, Izmir Biomedicine and Genome Ctr., Dokuz Eylül Üniv. (Turkey)
Ibrahim Akkaya, Izmir Biomedicine and Genome Ctr., Dokuz Eylül Üniv. (Turkey)
Asli Celik, Dokuz Eylül Üniv. (Turkey)
Basar Koc, Dokuz Eylül Üniv. (Turkey)
M. Ensari Guneli, Izmir Biomedicine and Genome Ctr., Dokuz Eylül Üniv. (Turkey)
Serhat Tozburun, Izmir Biomedicine and Genome Ctr., Dokuz Eylül Üniv. (Turkey)


Published in SPIE Proceedings Vol. 11238:
Optical Interactions with Tissue and Cells XXXI
Bennett L. Ibey; Norbert Linz, Editor(s)

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