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Proceedings Paper

The penetration and movement of nanoparticles on membrane
Author(s): Lianxin Xin; Zixuan Wang; Jian Zhao; Zachary Tyler; Hacene Boukari; Essaid Zerrad; Jun Ren
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Paper Abstract

In this study, we used GROMACS, a versatile package for performing molecular dynamics to simulate the interactions between different nanoparticles and Dipalmitoyl PhosPhatidyl Choline (DPPC) to understand the physical mechanisms that govern the interactions between nanoparticles and lipid membrane. Our simulations show the responses of the lipid bilayer to the nanoparticles, including the formation of an adsorbent layer on the nanoparticle surface, transmembrane ectopic movements and inconspicuous endocytosis of the nanoparticle by the membrane. Effects of the size of the nanoparticles, structural shape and charge state on the interaction and transport processes will be examined and summarized.

Paper Details

Date Published: 21 February 2020
PDF: 11 pages
Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560M (21 February 2020); doi: 10.1117/12.2544321
Show Author Affiliations
Lianxin Xin, Delaware State Univ. (United States)
Zixuan Wang, Delaware State Univ. (United States)
Jian Zhao, Delaware State Univ. (United States)
Zachary Tyler, Delaware State Univ. (United States)
Hacene Boukari, Delaware State Univ. (United States)
Essaid Zerrad, Delaware State Univ. (United States)
Jun Ren, Delaware State Univ. (United States)

Published in SPIE Proceedings Vol. 11256:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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