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Proceedings Paper

Light emitting diode based photoacoustic/ultrasound imaging reveals fast dynamic contrast in liver and changes in blood oxygenation (Conference Presentation)

Paper Abstract

High power light emitting diodes (LEDs) can serve as fast, robust and affordable excitation sources for photoacoustic imaging. We test the in vivo imaging capabilities of a multi-modal imaging platform that comprises of LED-based photoacoustic (PA) and conventional ultrasound imaging. We characterized the dynamics of a fluorescent contrast agent and modulation of tissue oxygenation in vivo. Fast dynamic PA imaging shows an increase in PA signal with increasing fluorescent agent concentration (Tmax ~ 8 min). Oxygen challenge studies revealed changes in blood oxygenation saturation (SO2) levels in relation to the modulation of breathing air and oxygen.

Paper Details

Date Published: 20 April 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400Q (20 April 2020); doi: 10.1117/12.2544317
Show Author Affiliations
James Joseph, Univ. of Cambridge (United Kingdom)
Mithun Kuniyil Ajith Singh, Cyberdyne, Inc. (Japan)
Naoto Sato, Cyberdyne, Inc. (Japan)
Sarah Bohndiek, Univ. of Cambridge (United Kingdom)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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