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Proceedings Paper

Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)
Author(s): Eno Hysi; Muhannad N. Fadhel; Anoja Giles; Yanjie Wang; Joseph A. Sebastian; Gregory J. Czarnota; Agata A. Exner; Michael C. Kolios

Paper Abstract

In this work, we examine the potential of photoacoustic imaging for understanding the biophysical mechanism of nanobubble and microbubble-based vascular disrupting therapies. We present for the first time, a direct in-vivo comparison between sub-micron nanobubbles and the commercially available microbubbles. Our results show that PA imaging of tumor oxygenation is capable of measuring the nanobubble-induced almost 40% cell death as a result of vascular disruption.

Paper Details

Date Published: 20 April 2020
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Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124029 (20 April 2020); doi: 10.1117/12.2544302
Show Author Affiliations
Eno Hysi, Ryerson Univ. (Canada)
Institute for Biomedical Engineering, Science and Technology (Canada)
Muhannad N. Fadhel, Ryerson Univ. (Canada)
Institute for Biomedical Engineering, Science and Technology (Canada)
Anoja Giles, Sunnybrook Research Institute (Canada)
Sunnybrook Health Sciences Ctr. (Canada)
Yanjie Wang, Ryerson Univ. (Canada)
Institute for Biomedical Engineering, Science and Technology (Canada)
Joseph A. Sebastian, Ryerson Univ. (Canada)
Institute for Biomedical Engineering, Science and Technology (Canada)
Gregory J. Czarnota, Sunnybrook Health Sciences Ctr. (Canada)
Agata A. Exner, Case Western Reserve Univ. (United States)
Michael C. Kolios, Ryerson Univ. (Canada)
Institute for Biomedical Engineering, Science and Technology (Canada)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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