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Proceedings Paper

Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering (Conference Presentation)

Paper Abstract

By virtue of its chemical specificity and label-free nature, Raman spectroscopy is a ubiquitous tool in analytical chemistry which has recently found increasing interest in biology and medicine, as technical improvements steadily enable applications. In particular, the low-frequency region of the Raman spectrum, which contains rich information about intermolecular interactions and higher-order structure, has promise for biological applications. However, detection of low-frequency modes remains a challenge with conventional techniques for Raman spectroscopy. Here, we propose and experimentally demonstrate Sagnac-enhanced impulsive stimulated Raman scattering (SE-ISRS), a method for time-domain Raman spectroscopy that provides highly sensitive low-frequency Raman spectra at all probe frequencies.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 1125107 (10 March 2020); doi: 10.1117/12.2544091
Show Author Affiliations
Walker Peterson, The Univ. of Tokyo (Japan)
Kotaro Hiramatsu, The Univ. of Tokyo (Japan)
Japan Science and Technology Agency (Japan)
Keisuke Goda, The Univ. of Tokyo (Japan)
Japan Science and Technology Agency (Japan)
Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 11251:
Label-free Biomedical Imaging and Sensing (LBIS) 2020
Natan T. Shaked; Oliver Hayden, Editor(s)

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