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Proceedings Paper

High-speed label-free galvo mirror scanning-based ultraviolet photoacoustic microscopy for histological imaging
Author(s): Xiufeng Li; Lei Kang; Yan Zhang; Terence T. W. Wong
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Paper Abstract

Ultraviolet-based photoacoustic microscopy (UV-PAM) has recently been demonstrated as a promising tool to overcome the time-consuming sample preparation procedure in traditional pathological analysis. In order to achieve high-speed UVPAM for clinical usage, we implemented UV-PAM with a single-axis galvo mirror scanner. With our UV laser operating at a repetition rate of 55 kHz, our system produced images ~5.5 times faster than the previously reported point-by-point raster scanning based UV-PAM, with a lateral resolution of ~1.0 μm. Histology-like images of a mouse brain slice were acquired by our system, showing its potential as an intraoperative imaging tool for surgical margin assessment.

Paper Details

Date Published: 17 February 2020
PDF: 6 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401X (17 February 2020); doi: 10.1117/12.2544071
Show Author Affiliations
Xiufeng Li, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Lei Kang, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Yan Zhang, Hong Kong Univ. of Science and Technology (Hong Kong, China)
Terence T. W. Wong, Hong Kong Univ. of Science and Technology (Hong Kong, China)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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