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Proceedings Paper • Open Access

In vivo optical imaging of vitiligo skin grafting treatment using multiphoton microscopy and reflectance confocal microscopy (Conference Presentation)
Author(s): Griffin R. Lentsch; Pezhman Mobasher; Craig Mizzoni; Karsten Koenig; Bruce Tromberg; Irene Georgakoudi; Anand Ganesan; Mihaela Balu

Paper Abstract

Vitiligo is characterized by white patches on skin due to the loss of melanocytes. Treatments are not uniformly successful and re-pigmentation is rarely complete. Optical laser scanning microscopy techniques have great potential to advance our understanding of the repigmentation process of vitiligo. In this pilot study, we employ in-vivo multiphoton microscopy (MPM) to assess potential changes in the metabolic state of epidermal keratinocytes involved in vitiligo before and throughout treatment, and in-vivo reflectance confocal microscopy (RCM) to assess the initiation of the re-pigmentation process and monitor wound healing after micro-grafting treatment.

Paper Details

Date Published: 6 March 2020
Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110O (6 March 2020); doi: 10.1117/12.2544056
Show Author Affiliations
Griffin R. Lentsch, Univ. of California, Irvine (United States)
Pezhman Mobasher, Univ. of California, Irvine (United States)
Craig Mizzoni, Tufts Univ. (United States)
Karsten Koenig, Univ. des Saarlandes (Germany)
Bruce Tromberg, National Institutes of Health (United States)
Irene Georgakoudi, Tufts Univ. (United States)
Anand Ganesan, Univ. of California, Irvine (United States)
Mihaela Balu, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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