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Proceedings Paper

Efficient segmentation of multi-modal optoacoustic and ultrasound images using convolutional neural networks
Author(s): Berkan Lafci; Elena Merćep; Stefan Morscher; Xosé Luís Deán-Ben; Daniel Razansky
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Paper Abstract

Multispectral optoacoustic tomography (MSOT) offers the unique capability to map the distribution of spectrally distinctive endogenous and exogenous substances in heterogeneous biological tissues by exciting the sample at various wavelengths and detecting the optoacoustically-induced ultrasound waves. This powerful functional and molecular imaging capability can greatly benefit from hybridization with pulse-echo ultrasound (US), which provides additional information on tissue anatomy and blood flow. However, speed of sound variations and acoustic mismatches in the imaged object generally lead to errors in the coregistration of compounded images and loss of spatial resolution in both imaging modalities. The spatially- and wavelength-dependent light fluence attenuation further limits the quantitative capabilities of MSOT. Proper segmentation of different regions and assignment of corresponding acoustic and optical properties turns then essential for maximizing the performance of hybrid optoacoustic and ultrasound (OPUS) imaging. Particularly, accurate segmentation of the boundary of the sample can significantly improve the images rendered. Herein, we propose an automatic segmentation method based on a convolutional neural network (CNN) for segmenting the mouse boundary in a pre-clinical OPUS system. The experimental performance of the method, as characterized with the Dice coefficient metric between the network output and the ground truth (manually segmented) images, is shown to be superior than that of a state-of-the-art active contour segmentation method in a series of two-dimensional (cross-sectional) OPUS images of the mouse brain, liver and kidney regions.

Paper Details

Date Published: 17 February 2020
PDF: 6 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402N (17 February 2020); doi: 10.1117/12.2543970
Show Author Affiliations
Berkan Lafci, ETH Zurich (Switzerland)
Univ. Zürich (Switzerland)
Elena Merćep, iThera Medical GmbH (Germany)
Stefan Morscher, iThera Medical GmbH (Germany)
Xosé Luís Deán-Ben, ETH Zurich (Switzerland)
Univ. Zürich (Switzerland)
Daniel Razansky, ETH Zurich (Switzerland)
Univ. Zürich (Switzerland)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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