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Proceedings Paper

Thermal-energy memory based photoacoustic thermometry (TEMPT) in deep tissue (Conference Presentation)
Author(s): Junjie Yao; Yuan Zhou; Mucong Li; Jianwen Luo; Pei Zhong

Paper Abstract

Photoacoustic (PA) tomography (PAT) is a promising technology for noninvasive temperature sensing. However, traditional PA thermometry can measure only the temperature changes relative to a baseline. Here we report a new thermal-energy-memory-based PA thermometry (TEMPT) to quantify the Grüneisen parameter and recover the absolute temperature distribution in deep tissues. We have validated the feasibility of TEMPT on tissue-mimicking phantoms and achieved a measurement accuracy of ~0.5 °C at 1.5 cm depth. As proof-of-concept, we applied TEMPT for temperature mapping during focused ultrasound treatment in mice in vivo. TEMPT is expected to find applications in thermotherapy on small animal models.

Paper Details

Date Published: 20 April 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402J (20 April 2020); doi: 10.1117/12.2543912
Show Author Affiliations
Junjie Yao, Duke Univ. (United States)
Yuan Zhou, Tsinghua Univ. (China)
Mucong Li, Duke Univ. (United States)
Jianwen Luo, Tsinghua Univ. (China)
Pei Zhong, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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