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Proceedings Paper

Super-multiplexed vibrational imaging for complex biomedicine (Conference Presentation)
Author(s): Wei Min

Paper Abstract

The rapidly increasing need for systems biology stimulates the development of super-multiplexed methods for simultaneous imaging multiple biomolecules with distinct colors. The consensus is that complex biology requires multiplex technology. Fluorescent microscopy has inherent limitation due to the fundamental color barrier. In this end, vibrational imaging coupled with novel probes has the potential to address this grand challenge. Here we will present our recent advance along this direction including novel probe development, new labeling and amplification protocols, and application to tissue imaging. Exciting results on super-resolution super-multiplex imaging and high-dimensional single cell analysis will be discussed.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112520S (10 March 2020); doi: 10.1117/12.2543897
Show Author Affiliations
Wei Min, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 11252:
Advanced Chemical Microscopy for Life Science and Translational Medicine
Ji-Xin Cheng; Wei Min; Garth J. Simpson, Editor(s)

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