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Proceedings Paper

Photodynamic therapy: apoptosis, paraptosis, and autophagy
Author(s): David Kessel; Won Jin Cho; Hyeong-Reh C. Kim
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Paper Abstract

Photodynamic therapy (PDT) can elicit different cellular responses depending on sub-cellular sites of photodamage. Targeting lysosomes or mitochondria leadd to death by apoptosis, while ER photodamage can result in apoptosis and paraptosis. Autophagy is cytoprotective unless lysosomes are the primary target. We propose that the optimal targeting profile involves lysosomes, mitochondria and ER. Lysosomal phototoxicity is not limited by autophagy and can promote pro-apoptotic effects that magnify the lethality of mitochondrial photodamage. Targeting ER can be effective even in cells with an impaired apoptotic program since this will not affect paraptotic death.

Paper Details

Date Published: 19 February 2020
PDF: 5 pages
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122002 (19 February 2020); doi: 10.1117/12.2543895
Show Author Affiliations
David Kessel, Wayne State Univ. School of Medicine (United States)
Won Jin Cho, Wayne State Univ. School of Medicine (United States)
Hyeong-Reh C. Kim, Wayne State Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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