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Proceedings Paper

Confocal video microscopy reveals altered leukocyte-endothelial interactions in skin preceding acute graft-versus-host disease (Conference Presentation)

Paper Abstract

Through noninvasive monitoring of leukocyte motion in skin capillaries of patients after hematopoietic cell transplantation, we found increased leukocyte rolling and adhesion prior to clinical signs of disease. In this longitudinal pilot study, we explored the feasibility to detect changes in leukocyte-endothelial interactions that precede acute graft-versus-host disease in patients after hematopoietic cell transplantation. We present the pattern of change in leukocyte rolling and adhesion in three patients over the course of the first 100 days post-transplant. Our preliminary data show increased leukocyte-endothelial interactions prior to clinical signs of any organ acute graft-versus-host disease.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110G (6 March 2020); doi: 10.1117/12.2543808
Show Author Affiliations
Inga Saknite, Vanderbilt Univ. Medical Ctr. (United States)
Michael Byrne, Vanderbilt Univ. Medical Ctr. (United States)
Madan Jagasia, Vanderbilt Univ. Medical Ctr. (United States)
Eric R. Tkaczyk, U.S. Dept. of Veterans Affairs (United States)
Vanderbilt Univ. Medical Ctr. (United States)
Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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