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Proceedings Paper

Phage susceptibility testing with lensless imaging technique (Conference Presentation)
Author(s): Prisca Perlemoine; Emmanuel Picard; Emmanuel Hadji; Marc Zelsmann; Alexis Maire; Eric Lacot; Pierre Marcoux

Paper Abstract

With the rise of antibiotic resistance, phage therapy is seen as a promising alternative to cure infection to multiresistant bacteria strains. However, phage susceptibility tests currently carried out are time-consuming and are not compliant with the automated environment of hospital laboratories. In this work, we present a method for phage susceptibility testing through optical density measurement with the use of lensless imaging technique. Using a 3.3 cm2 area CANON sensor and a custom test card, we are able to simultaneously monitor the bacterial growth or inhibition of multiple bacterial/phage samples and to provide reliable results in less than 4 hour.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230D (10 March 2020);
Show Author Affiliations
Prisca Perlemoine, CEA-Grenoble (France)
Emmanuel Picard, Univ. Grenoble Alpes (France)
CEA - Institut de Recherche Interdisciplinaire de Grenoble (France)
Emmanuel Hadji, Univ. Grenoble Alpes (France)
CEA - Institut de Recherche Interdisciplinaire de Grenoble (France)
Marc Zelsmann, Univ. Grenoble Alpes (France)
Lab. des Technologies de La Microélectronique (France)
Alexis Maire, Univ. Grenoble Alpes (France)
Lab. des Technologies de La Microélectronique (France)
Eric Lacot, Univ. Grenoble Alpes (France)
Lab. Interdisciplinaire de Physique (France)
Pierre Marcoux, Univ. Grenoble Alpes (France)
Lab. d'Electronique de Technologie de l'Information (France)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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