Heterogeneities of biological tissues can strongly affect light propagation at large depths by distorting the initial wavefront. Inspired by previous works in acoustics, we have developed a matrix approach to Full-Field Optical Coherence Tomography (FF-OCT) to push back the fundamental limit of aberrations and multiple scattering. An analysis of the correlations of the matrix allows to correct for aberrations and forward multiple scattering over multiple isoplanatic areas (contrary to classic adaptive optics). Here, we report on the application of this approach to the imaging of the monkey cornea and the quantitative measurement of the corneal transparency.

Date Published: 11 March 2020
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Proc. SPIE 11248, Adaptive Optics and Wavefront Control for Biological Systems VI, 112480M (11 March 2020); doi: 10.1117/12.2543707

Published in SPIE Proceedings Vol. 11248:
Adaptive Optics and Wavefront Control for Biological Systems VI
Thomas G. Bifano; Sylvain Gigan; Na Ji, Editor(s)