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Proceedings Paper

Wide-field multispectral photoacoustic imaging of human melanomas in vivo
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Paper Abstract

Cutaneous melanoma accounts for only 5% of skin cancer, but it is as dangerous as it is associated with 75% skincancer- related deaths. Clinical decision-making and prognosis is the thickness of melanoma into the tissue. Another feature is that the cancer that can occur anywhere on the body, including the face, chest, thigh, soles, and groin, and its size is also very diverse. Here, we developed a hand-held scanner and obtained 3D photoacoustic images of in vivo human melanoma by using multispectral real-time clinical photoacoustic and ultrasound imaging system with the scanner. The scanner allowed wide-field scanning of 3.8 cm (transducer aperture size) × 3 cm (scanning range). Four patients were recruited to obtain photoacoustic melanoma images of various sites (thigh, sole, etc.), types (in situ, invasive, etc.) and sizes (sub-mm to cm). Five wavelengths were used to perform spectral unmixing. The penetration depth of melanoma was successfully confirmed by the multispectral photoacoustic images. The melanoma depth measured by photoacoustic imaging was significantly similar to histopathologic results obtained after excision (mean absolute error = 0.6 mm). In this study, we acquired small-to-large size and various types of melanoma multispectral photoacoustic images in vivo. We hope that this study will be an additional criterion for histopathological results that may have a positive impact on the diagnosis, treatment, and prognosis of melanomas.

Paper Details

Date Published: 17 February 2020
PDF: 4 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124006 (17 February 2020); doi: 10.1117/12.2543652
Show Author Affiliations
Byullee Park, Pohang Univ. of Science and Technology (Korea, Republic of)
Chul Hwan Bang, The Catholic Univ. of Korea (Korea, Republic of)
Changyeop Lee, Pohang Univ. of Science and Technology (Korea, Republic of)
Ju Hee Han, The Catholic Univ. (Korea, Republic of)
Jeesu Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Wonseok Choi, Pohang Univ. of Science and Technology (Korea, Republic of)
Gyeong Sin Park, The Catholic Univ. (Korea, Republic of)
Jong Won Rhie, The Catholic Univ. (Korea, Republic of)
Ji Hyun Lee, The Catholic Univ. (Korea, Republic of)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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