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Proceedings Paper

Directly extracting the optical transport coefficients of a turbid medium via time-resolved diffuse reflectance: a Monte Carlo study
Author(s): Michael Helton; Mary-Ann Mycek; Karthik Vishwanath
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Paper Abstract

An empirical approach to estimate the reduced scattering (μs’) and absorption (μa) coefficients of a turbid medium from time-resolved diffuse reflectance detected at multiple source-detector separations (SDS) is described. The dependence of the temporal point spread function (TPSF) on the medium’s optical properties has been previously well studied. Here, we exploit these findings by using the difference in photon arrival-times obtained from a pair of SDS at the (a) peak intensity and (b) longer-time trailing edge of the TPSF to estimate the transport coefficients. This difference may have little dependence on the instrument response functions (IRF). Consequently, real-time quantitation is possible since the method does not depend on non-linear fitting of measured reflectance and/or deconvolving the IRF. The approach uses Monte Carlo simulations to directly translate the difference in arrival times of the temporal reflectance profiles at multiple SDS into the medium’s optical properties. Here, we show that a small range in the optical properties could be defined using a pair of time differences in the TPSF.

Paper Details

Date Published: 21 February 2020
PDF: 6 pages
Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 112530O (21 February 2020); doi: 10.1117/12.2543610
Show Author Affiliations
Michael Helton, Univ. of Michigan (United States)
Mary-Ann Mycek, Univ. of Michigan (United States)
Karthik Vishwanath, Miami Univ. (United States)

Published in SPIE Proceedings Vol. 11253:
Biomedical Applications of Light Scattering X
Adam Wax; Vadim Backman, Editor(s)

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