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Proceedings Paper

The development of radiogenetically-controlled signaling proteins for novel applications to optogenetics
Author(s): Morgan S. Schmidt; Saber Hussain; Patrick Dennis; Sanaz Farajollahi; Ruth Pachter
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Paper Abstract

Recent development of light-controlled cellular activity, known as optogenetics, has sparked interest in new methods for neural and cellular activation. Since its inception, optogenetics has impacted neuroscience research in many ways providing new insight into the functioning of neuronal circuitry. Even though great strides have been made in this community, there is still much to be discovered. Therefore, there is a need for improvements and innovative capabilities for light delivery and control. Although there are many avenues to overcome these limitations, we propose the use of non-traditional optogenetic wavelengths in order to move towards a non-invasive optogenetic approach. Alternatives to optogenetics techniques have been developed and coined “thermogenetics,” “magnetogenetics,” and “radiogenetics.” For example, the use of radio frequencies (RFs) to drive cellular stimulation has been shown to provide a big advantage in remote modulation of signaling pathways because it is non-invasive, easily adaptable and does not require the insertion of electrodes. Thus, our goal was to branch out from traditional optogenetics and focus on the mechanistic properties of RFs on proteins and cellular pathways in order to drive the future use of non-traditional optogenetics. In this work, we proposed to synthetically generate a new sensing element to enable its potential modulation by RF fields. The ability to remotely modulate the expression of novel sensing proteins would provide a tool to better understand the human neuronal network as well as develop a technique towards the improvement of human performance.

Paper Details

Date Published: 19 February 2020
PDF: 6 pages
Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270F (19 February 2020);
Show Author Affiliations
Morgan S. Schmidt, Air Force Research Lab. (United States)
Saber Hussain, Air Force Research Lab. (United States)
Patrick Dennis, Air Force Research Lab. (United States)
Sanaz Farajollahi, Air Force Research Lab. (United States)
Ruth Pachter, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 11227:
Optogenetics and Optical Manipulation 2020
Samarendra K. Mohanty; E. Duco Jansen; Anna W. Roe, Editor(s)

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