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Proceedings Paper

Clinical implementation of model-based dose planning for indoor daylight photodynamic therapy of skin (Conference Presentation)
Author(s): Ethan Philip M. LaRochelle; Alberto J. Ruiz; M. Shane Chapman; Edward V. Maytin; Tayyaba Hasan; Brian W. Pogue

Paper Abstract

In recent years much work has been done to show treatment efficacy using daylight as the activation mechanism of PpIX-based PDT for non-melanoma skin cancers and pre-cancerous actinic keratosis. Many previous studies assume sufficient fluence is delivered during a 2-3 hour period, but fail to consider shifts in the UV spectral composition throughout the day and transient weather conditions. Using a model-based approach we have developed a dose planning application to provide clinicians with information regarding minimum necessary treatment times. Clinical photobleaching data comparing indoor daylight and conventional red-light PDT have been collected to test the viability of this model.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122006 (10 March 2020); doi: 10.1117/12.2543536
Show Author Affiliations
Ethan Philip M. LaRochelle, Dartmouth College (United States)
Alberto J. Ruiz, Dartmouth College (United States)
M. Shane Chapman, Geisel School of Medicine, Dartmouth College (United States)
Edward V. Maytin, Lerner Research Institute - Cleveland Clinic (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Brian W. Pogue, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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