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Proceedings Paper

Stimuli-responsive 3D micro-scaffolds for single cell actuation (Conference Presentation)
Author(s): Marc Hippler; Kai Weißenbruch; Enrico Lemma; Eva Blasco; Motomu Tanaka; Christopher Barner-Kowollik; Martin Bastmeyer; Martin Wegener

Paper Abstract

We introduce stimuli-responsive structures fabricated by 3D laser lithography. The key material is a responsive hydrogel. It is based on supramolecular host-guest chemistry, which allows reversible actuation under physiological conditions. Combined with other photoresists, multi-material scaffolds are used to directly study live cell behavior during spatially and temporally well-defined changes in the extracellular surrounding. Digital image correlation enables us to precisely track and analyze the behavior of a multitude of cells in a single experiment. With this versatile technique we will study the mechanoresponse of cells and the role of different proteins in the mechanotransduction.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11271, Laser 3D Manufacturing VII, 1127110 (9 March 2020); doi: 10.1117/12.2543477
Show Author Affiliations
Marc Hippler, Karlsruher Institut für Technologie (Germany)
Kai Weißenbruch, Karlsruher Institut für Technologie (Germany)
Enrico Lemma, Karlsruher Institut für Technologie (Germany)
Eva Blasco, Karlsruher Institut für Technologie (Germany)
Motomu Tanaka, Ruprecht-Karls-Univ. Heidelberg (Germany)
Christopher Barner-Kowollik, Queensland Unv. of Technology (Australia)
Martin Bastmeyer, Karlsruher Institut für Technologie (Germany)
Martin Wegener, Karlsruher Institut für Technologie (Germany)

Published in SPIE Proceedings Vol. 11271:
Laser 3D Manufacturing VII
Bo Gu; Hongqiang Chen; Henry Helvajian, Editor(s)

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