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Proceedings Paper

Eliminating drug-resistant bacteria and fungal infections via one-photon and multi-photon bleaching of intrinsic chromophores (Conference Presentation)
Author(s): Ji-Xin Cheng

Paper Abstract

Antibiotic resistance kills an estimated 700,000 people each year worldwide, and study predicts that this number could rise to 10 million by 2050 if efforts are not made to curtail resistance (Nature, 2017, 543:15). Yet, the pace of resistance acquisition from mutation in pathogens is faster than clinical introduction of new antibiotics. This severe situation calls for an urgent need of developing unconventional ways to combat the resistance. To tackle this challenge, we are developing a novel phototherapy platform for fighting against a broad spectrum of drug-resistant infections. In particular, we have found that many intrinsic chromophores are probe to photobleaching through one-photon and even two-photon absorption. Importantly, these chromophores are virulence factors or essential for bacteria to survive in a stressed condition. Thus, photo-destruction of these intrinsic chromophores sensitizes the bacteria to attack by ROS or conventional antibiotics. Unlike photodynamic therapy,

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112440K (9 March 2020); doi: 10.1117/12.2543378
Show Author Affiliations
Ji-Xin Cheng, Boston Univ. (United States)

Published in SPIE Proceedings Vol. 11244:
Multiphoton Microscopy in the Biomedical Sciences XX
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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