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Proceedings Paper

Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)
Author(s): Ariel I. Mundo; Elizabeth Bullard; Kyle P. Quinn; Timothy J. Muldoon

Paper Abstract

Ulcerative Colitis (UC) is an idiopathic autoimmune inflammatory disorder of the colon mucosa characterized by leukocyte infiltration into the submucosa and ulcer formation in the epithelium, followed by epithelial cell proliferation and restitution of the mucosal barrier. Optical methods sensitive to tissue oxygen demand and epithelial cell metabolism are ideally suited for clinical guidance of disease progression and remission in UC. Here we present endoscopic reporters of submucosal oxygen demand (i.e. inflammatory-related changes) and epithelial cell metabolism (i.e. mucosal re-epithelialization) within the ulcer bed and surrounding microenvironment in a murine model of UC as putative biomarkers of mucosal healing.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121605 (9 March 2020); doi: 10.1117/12.2543369
Show Author Affiliations
Ariel I. Mundo, Univ. of Arkansas (United States)
Elizabeth Bullard, Univ. of Arkansas (United States)
Kyle P. Quinn, Univ. of Arkansas (United States)
Timothy J. Muldoon, Univ. of Arkansas (United States)

Published in SPIE Proceedings Vol. 11216:
Multiscale Imaging and Spectroscopy
Paul J. Campagnola; Kristen C. Maitland; Darren M. Roblyer, Editor(s)

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