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Proceedings Paper

Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)

Paper Abstract

Label-free multiphoton imaging has been a powerful tool to study the microstructure and specific chemical distributions in biological tissue, especially in tumors and their microenvironments. Thus, this technique has great potential to assist in cancer-related clinical studies. A portable label-free multiphoton imaging system was constructed with four imaging modalities: two- and three- photon fluorescence, and second and third harmonic generation. Mosaicked multimodal images can be acquired with dual-channel detection and galvo-mirror scanning. This system was demonstrated during animal surgeries for real-time, label-free assessment of tumor tissue samples acquired via core-needle biopsy and fine-needle aspiration.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340X (9 March 2020); doi: 10.1117/12.2543216
Show Author Affiliations
Lingxiao Yang, Univ. of Illinois (United States)
Yi Sun, Univ. of Illinois (United States)
Darold R. Spillman Jr., Univ. of Illinois (United States)
Sixian You, Univ. of Illinois (United States)
Stephen A. Boppart, Univ. of Illinois (United States)


Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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