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Proceedings Paper

Magnetically aggregated biosensors for sensitive detection of biomarkers at low concentrations (Conference Presentation)

Paper Abstract

Detection of biomarkers at low concentrations is essential for early diagnosis of numerous diseases. In many sensitive assays, the target molecules are tagged using fluorescently labeled probes and captured using magnetic beads. Current devices rely on quantifying the target molecules by detecting the fluorescent signal from individual beads. Here, we propose a compact fluorescence-based magnetically aggregated biosensors (MAB) system. Using the device to detect human Interleukin-8, we demonstrated a 0.1 ng/L limit of detection and a 4-log dynamic range, performance which is on par with the most sensitive devices, but is achieved without their bulk and cost.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125803 (10 March 2020); doi: 10.1117/12.2543206
Show Author Affiliations
Shmuel Burg, Bar-Ilan Univ. (Israel)
Meir Cohen, Bar-Ilan Univ. (Israel)
Michael Margulis, Bar-Ilan Univ. (Israel)
Shira Roth, Bar-Ilan Univ. (Israel)
Amos Danielli, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 11258:
Frontiers in Biological Detection: From Nanosensors to Systems XII
Amos Danielli; Benjamin L. Miller; Sharon M. Weiss, Editor(s)

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