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Proceedings Paper

The classification of blood cell via contrast-enhanced microholography and deep learning
Author(s): Chia-Sheng Kuo; Yi-Chun Chen; Zhi-Zhong Wang; Hsiang-Yu Lei; Can-Hua Yang; Chen-Han Huang
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Paper Abstract

Human blood analysis has provided rich information in rapid clinical diagnosis. Different from conventional blood cell counting method which is environment-dependent and costly, this study proposes an advanced blood cells imaging method at micron-scale to reduce the size of the equipment and decrease the total cost of testing. This approach applies the deep learning method and a convolutional neural network in reconstructing object images from the diffraction patterns. The holographic image is extracted by the convolution layer and the feature classification of the hidden layer rapidly identifies each diffraction pattern of the holographic image. The mean IoU for masks generated from the hologram is 0.876. Consequently, this deep learning approach is significantly more preferable to conventional calculation. It, thus, provides a portable, compact and cost-effective contrast-enhanced microholography system for clinical diagnosis.

Paper Details

Date Published: 17 February 2020
PDF: 4 pages
Proc. SPIE 11231, Design and Quality for Biomedical Technologies XIII, 112310D (17 February 2020); doi: 10.1117/12.2543131
Show Author Affiliations
Chia-Sheng Kuo, National Central Univ. (Taiwan)
Yi-Chun Chen, National Central Univ. (China)
Zhi-Zhong Wang, National Central Univ. (China)
Hsiang-Yu Lei, National Central Univ. (China)
Can-Hua Yang, National Central Univ. (China)
Chen-Han Huang, National Central Univ. (China)

Published in SPIE Proceedings Vol. 11231:
Design and Quality for Biomedical Technologies XIII
Jeeseong Hwang; Gracie Vargas, Editor(s)

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