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Proceedings Paper

Inhibiting staphylococcus aureus antibiotic resistance via photo-disassembly of membrane microdomains
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Paper Abstract

The rapid evolution of antibiotic resistance increasingly challenges the successful treatment of S. aureus infections. Here, we present an unconventional treatment approach by disassembly its membrane microdomains via pulsed laser photolysis of staphyloxanthin. After staphyloxanthin photolysis, membrane permeabilization, fluidification, and membrane protein detachment, were found the underlying mechanisms to malfunction its defense to several major classes of conventional antibiotics. Through resistance selection study, we found pulsed laser treatment completely depleted staphyloxanthin virulence. More importantly, laser treatment further inhibited development of resistance for several major classes of conventional antibiotics including fluoroquinolones, tetracyclines, aminoglycosides, and oxazolidinones. Collectively, this work highlights a novel platform to revive conventional antibiotics to treat S. aureus infections.

Paper Details

Date Published: 19 February 2020
PDF: 4 pages
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230T (19 February 2020); doi: 10.1117/12.2543045
Show Author Affiliations
Jie Hui, Boston Univ. (United States)
Pu-Ting Dong, Boston Univ. (United States)
Lijia Liang, Jilin Univ. (China)
Taraknath Mandal, Boston Univ. (United States)
Junjie Li, Boston Univ. (United States)
Erlinda R. Ulloa, Univ. of California, San Diego (United States)
Yuewei Zhan, Boston Univ. (United States)
Sebastian Jusuf, Boston Univ. (United States)
Cheng Zong, Boston Univ. (United States)
Mohamed N. Seleem, Purdue Univ. (United States)
George Y. Liu, Univ. of California, San Diego (United States)
Rady Children's Hospital (United States)
Qiang Cui, Boston Univ. (United States)
Ji-Xin Cheng, Boston Univ. (United States)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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