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Proceedings Paper

Improving temporal resolution of fNIRS-DOT by the guidance of data-reduced pre-OT
Author(s): Dongyuan Liu; Bingyuan Wang; Yao Zhang; Tiantian Pan; Yang Liu; Feng Gao
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Paper Abstract

Functional near-infrared spectroscopy techniques, in the form of either optical topography (OT) or diffuse optical tomography (DOT), can non-invasively recover the hemodynamic changes occurring in the activated cerebral cortex. In comparison with the traditional OT that provides a less quantitative absorption perturbation map along the subject domain surface, a successful DOT has ability to quantify depth-resolved information that relies on abundant boundary overlapping measurements using a high-density (HD) source-detector array. To achieve a trade-off between the temporal resolution and sensitivity by channel cross-talk suppression, a hybrid frequency- and time-division-multiplexing strategy have to be normally adopted to the HD-DOT implementation, where the temporal resolution degradation due to the multi-field illuminations might still prevent from capturing the high frequency information. In this work, a deep-learning based pre-OT method has been proposed to improve the temporal resolution of HD-DOT. The pre-OT could provide prior information on activation regions to exclude measurements of non-sensitive data. We have performed simulation and phantom experiments to evaluate the performances of the proposed method, and demonstrated its superiority over the stand-alone HD-DOT in improving both the temporal resolution and localization accuracy.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341J (21 February 2020); doi: 10.1117/12.2542977
Show Author Affiliations
Dongyuan Liu, Tianjin Univ. (China)
Bingyuan Wang, Tianjin Univ. (China)
Yao Zhang, Tianjin Univ. (China)
Tiantian Pan, Tianjin Univ. (China)
Yang Liu, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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