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Proceedings Paper

Imaging layered mucosa with visible modulated light (Conference Presentation)
Author(s): Min Xu; Yang Zheng; Da Pan; Xiafei Qian; Weihao Lin; Bixin Zeng

Paper Abstract

Most cancers originate from epithelium, the top layer of mucosa. We report single-snapshot Spatial Frequency Domain Imaging (SFDI) of mucosa with visible modulated light. A novel two-layer mucosa model enables the mapping of the total hemoglobin concentration, the oxygen saturation, the scattering characteristics of the top and bottom layers, and the thickness of the top layer from a single-snapshot. After validating with phantom studies, we demonstrate its applicability to the characterization of mucosa by imaging human mouth lips of healthy subjects. The proposed approach may find important applications in screening mucosa for early detection of cancer and other diseases.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11243, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII, 112430M (9 March 2020); doi: 10.1117/12.2542976
Show Author Affiliations
Min Xu, The City Univ. of New York (United States)
Yang Zheng, Wenzhou Medical Univ. (China)
Da Pan, Wenzhou Medical Univ. (China)
Xiafei Qian, Wenzhou Medical Univ. (China)
Weihao Lin, Wenzhou Medical Univ. (China)
Bixin Zeng, Wenzhou Medical Univ. (China)

Published in SPIE Proceedings Vol. 11243:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII
Daniel L. Farkas; Attila Tarnok, Editor(s)

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