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Proceedings Paper

Retinal pigment epithelium-melanin specific contrast imaging by multi-contrast OCT
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Paper Abstract

We used multi-contrast OCT (MC-OCT), which is capable of the simultaneous measurement of OCT angiography, degree of polarization uniformity and intensity OCT, to evaluate retinal pigment epithelium (RPE) changes. MC-OCT system was operated at an axial scan speed of 100,000 A-scans/s, using a swept-source laser at a central wavelength of 1,048 nm. From the dataset of MC-OCT, a pixel-wise segmentation method for RPE-melanin was developed and used to create RPE-melanin-specific contrast images to evaluate RPE-melanin changes. The RPE-melanin cross-sectional images were generated to evaluate the depth-resolved distribution of RPE-melanin. RPE-melanin thickness maps were created by counting the number of pixels with RPE-melanin at each A-line in the 3D dataset. An RPE-melanin thickness map represents the en face distribution of the thickness of RPE-melanin. We evaluated 37 eyes with age-related macular degeneration (AMD) with serous retinal pigment epithelium detachment, and 24 eyes with chronic Vogt-Koyanagi- Harada (VKH) disease. In these cases, RPE-melanin thickness maps showed similarities to the near infrared autofluorescence (NIR-AF; excitation 780 nm) images. In the eyes with AMD, focal RPE damages could be readily detected with RPE-melanin thickness map. RPE-melanin cross-sectional images were more sensitive for the damage at RPE-Bruch’s membrane band than intensity OCT images. In the eyes with VKH disease, RPE-melanin-specific contrast images clearly showed focal RPE-melanin accumulation at granular hyper NIR-AF lesions. In conclusion, this study demonstrated the clinical usefulness of RPE-melanin specific contrast OCT imaging for evaluating RPE changes in retinal diseases.

Paper Details

Date Published: 19 February 2020
PDF: 6 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181H (19 February 2020); doi: 10.1117/12.2542922
Show Author Affiliations
Masahiro Miura, Ibaraki Medical Ctr., Tokyo Medical Univ. (Japan)
Shuichi Makita, Univ. of Tsukuba (Japan)
Shinnosuke Azuma, Topcon Corp. (Japan)
Yoshiaki Yasuno, Univ. of Tsukuba (Japan)
Toshihiro Mino, Topcon Corp. (Japan)
Tatsuo Yamaguchi, Topcon Corp. (Japan)
Satoshi Sugiyama, Tomey Corp. (Japan)
Takuya Iwasaki, Ibaraki Medical Ctr., Tokyo Medical Univ. (Japan)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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