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Proceedings Paper

Intraoperative margin assessment of breast-conserving surgery resections using x-ray micro-computed tomography and optical structured light (Conference Presentation)
Author(s): Samuel S. Streeter; Benjamin W. Maloney; Elizabeth J. Rizzo; Michael Jermyn; Wendy A. Wells; Richard J. Barth Jr.; Keith D. Paulsen; Brian W. Pogue

Paper Abstract

The most common treatment for early-stage breast cancer involves breast-conserving surgery (BCS), which is a local resection of malignant tissue. BCS success relies on the presence of healthy tissue margins surrounding each resection. However, approximately 20% of BCS patients require follow-up surgery to remove residual tumor. Micro-computed tomography and optical structured light imaging were investigated for intraoperative margin assessment. Specimens were imaged immediately after resection and before surgical inking, and image data were compared to postoperative histopathology. The study demonstrated the feasibility of imaging during BCS and generated a baseline multimodal dataset of whole BCS resections, including positive margin signatures.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11232, Multimodal Biomedical Imaging XV, 112320C (9 March 2020); doi: 10.1117/12.2542827
Show Author Affiliations
Samuel S. Streeter, Thayer School of Engineering at Dartmouth (United States)
Benjamin W. Maloney, Thayer School of Engineering at Dartmouth (United States)
Elizabeth J. Rizzo, Dartmouth-Hitchcock Medical Ctr. (United States)
Michael Jermyn, Thayer School of Engineering at Dartmouth (United States)
Wendy A. Wells, Dartmouth-Hitchcock Medical Ctr. (United States)
Richard J. Barth Jr., Dartmouth-Hitchcock Medical Ctr. (United States)
Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 11232:
Multimodal Biomedical Imaging XV
Fred S. Azar; Xavier Intes; Qianqian Fang, Editor(s)

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