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Proceedings Paper

Laser-patterned lateral-flow devices with multiple flow-paths for semi-quantitative measurement of the inflammatory biomarker, C-reactive protein (Conference Presentation)
Author(s): Alice Iles; Peijun J. W. He; Ioannis N. Katis; Panagiotis Galanis; Anto J. Kumar; Jessica L. Teeling; Clive Holmes; Jay Amin; Robert W. Eason; Collin L. Sones

Paper Abstract

We report a novel solution for semi-quantitative detection of C-reactive protein (CRP), a common inflammatory marker, using a multi-path lateral-flow device (LFD) fabricated via the precise partitioning of the single flow-path of a standard LFD using a laser direct-write technique. The multiple isolated flow-paths allow detection of different concentrations by individually setting different cut-off levels. The semi-quantitative readout is observed via simple appearance/absence of test lines without the need for a reader or further analyses. We have successfully demonstrated the use of these multi-path LFDs for semi-quantitative detection of CRP and will present validation in human samples.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 1123507 (9 March 2020); doi: 10.1117/12.2542692
Show Author Affiliations
Alice Iles, Univ. of Southampton (United Kingdom)
Peijun J. W. He, Univ. of Southampton (United Kingdom)
Ioannis N. Katis, Univ. of Southampton (United Kingdom)
Panagiotis Galanis, Univ. of Southampton (United Kingdom)
Anto J. Kumar, Univ. of Southampton (United Kingdom)
Jessica L. Teeling, Univ. of Southampton (United Kingdom)
Clive Holmes, Univ. of Southampton (United Kingdom)
Jay Amin, Univ. of Southampton (United Kingdom)
Robert W. Eason, Univ. of Southampton (United Kingdom)
Collin L. Sones, Univ. of Southampton (United Kingdom)

Published in SPIE Proceedings Vol. 11235:
Microfluidics, BioMEMS, and Medical Microsystems XVIII
Bonnie L. Gray; Holger Becker, Editor(s)

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