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Proceedings Paper

Assessment of variable block lengths during infrared neural inhibition (Conference Presentation)
Author(s): Jeremy B. Ford; Michael W. Jenkins; Hillel J. Chiel; E. Duco Jansen

Paper Abstract

Infrared neural inhibition (INI) is a method of blocking the generation or propagation of neural action potentials through heating with infrared lasers that target peaks in the water absorption spectrum (1460 nm, 1875 nm). Recent work showed that the length of axon heated modulates the temperature needed for inhibition. Different irradiation lengths for INI were tested in Aplysia nerves (n=7). Once 1 mm of irradiation was exceeded, longer irradiation lengths resulted in higher temperatures at inhibition threshold. Optimizing irradiation lengths of nerve to minimize temperatures will help inform the design of devices for longitudinal animal studies and human implementation.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270M (9 March 2020); doi: 10.1117/12.2542543
Show Author Affiliations
Jeremy B. Ford, Vanderbilt Univ. (United States)
Michael W. Jenkins, Case Western Reserve Univ. (United States)
Hillel J. Chiel, Case Western Reserve Univ. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 11227:
Optogenetics and Optical Manipulation 2020
Samarendra K. Mohanty; E. Duco Jansen; Anna W. Roe, Editor(s)

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