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Proceedings Paper

Investigation of active matrix-metaloproteinase-8 (aMMP-8) as a reference parameter for path control in antimicrobial photothermal therapy (aPTT) using a split-mouth design
Author(s): J. Deumer; M. Frentzen; M. C. Meinke
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Paper Abstract

Objectives

This retrospective data-collection study aims to explain how the active matrix metalloproteinase-8-titer (aMMP-titer) influences the immune response of the subject. This is done through monotherapy scaling and root planing (SRP) which is then compared to SRP combined with antimicrobial photothermal therapy (aPTT, Emundo).

Methods

Data collection was monocentric, randomized and split-mouth based. A study group of twenty patients with chronic periodontal disease with a periodontal pocket depth (PPD) 4 mm ≤ PPD ≤ 8 mm, a periodontal screening index (PSI: > 3), and a gingival recession ≤ 2 mm were selected. A diode laser, manufactured by A.R.C. Laser GmbH, with 810 nm wavelength was used. This device implemented three different light transmission systems for transgingival and intra-gingival irradiation. Power settings between 200 and 300 mW were deployed for ten seconds during all treatment steps. The photothermic dye of EmunDo system (A.R.C. Laser GmbH) was infracyaningreen. The adjuvant effect of the antimicrobial photothermal therapy (aPTT) with EmunDo in combination with conventional SRP on the teeth 15 and 35 was compared with the results of monotherapy SRP on teeth 25 and 45.

Results

A reduction of the aMMP-8-titer in gingival crevicular fluid (GCF) was observed in both groups (follow up group and control group) after one month. However; the decrease in the follow up group under SRP in combination with aPTT was significantly more pronounced. The periodontal pocket depths was reduced in both treatment groups. The periodontal probing depth (in mm) shows a larger decrease of the periodontal pocket depth within the follow up group (SPR with aPTT) compared with the control group (SRP).

Conclusion

The aMMP-8-titer showed differences in both groups prior to and after treatment. Active matrix- metalloproteinase-8 (aMMP-8) as a reference parameter for path control in antimicrobial photothermal therapy (aPTT) seems acceptable.

Paper Details

Date Published: 24 February 2020
PDF: 23 pages
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230V (24 February 2020); doi: 10.1117/12.2542333
Show Author Affiliations
J. Deumer, MVZ Erstes Zahnärztliches Lasercentrum Berlin (Germany)
M. Frentzen, Univ. Bonn (Germany)
M. C. Meinke, Charité Universitätsmedizin Berlin (Germany)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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