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Proceedings Paper

Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser
Author(s): Karsten König; Ana Batista; Michael Zieger; Martin Kaatz; Holger Hänssle; Christine Fink; Hans Georg Breunig
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Paper Abstract

Multiphoton tomography (MPT) has become a high-resolution label-free clinical imaging tool to obtain optical skin biopsies for rapid in vivo histology. Here, we report on the novel multimodal multiphoton tomograph MPT compact based on a chiller-free ultracompact 80 MHz femtosecond fiber laser operating at 780 nm. The 360°-measurement head contains the laser head and multiple photon detectors for (i) autofluorescence (AF) imaging, (ii) fluorescence lifetime imaging (FLIM) for optical metabolic imaging (OMI) and melanin detection, (iii) second harmonic imaging (SHG) of collagen, (iv) confocal reflection microscopy (CRM), and (v) white-light imaging (dermoscopy). Preliminary results of an ongoing multicenter clinical study in patients with suspicious pigmented lesions in two hospitals are presented.

Paper Details

Date Published: 24 February 2020
PDF: 8 pages
Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110E (24 February 2020); doi: 10.1117/12.2542322
Show Author Affiliations
Karsten König, JenLab GmbH (Germany)
Saarland Univ. (Germany)
Ana Batista, Saarland Univ. (Germany)
Michael Zieger, SRH Wald-Klinikum Gera GmbH (Germany)
Martin Kaatz, SRH Wald-Klinikum Gera GmbH (Germany)
Holger Hänssle, Heidelberg Univ. Hospital (Germany)
Christine Fink, Heidelberg Univ. Hospital (Germany)
Hans Georg Breunig, JenLab GmbH (Germany)
Saarland Univ. (Germany)


Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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